Silverknowes Road will be closed from tomorrow for a minimum of three weeks to allow pedestrians and cyclists to travel safely while observing social distancing guidance.
The move comes after the council received support from a £10m fund to help local authorities introduce temporary active travel solutions.
The council have been working closely with Transport Scotland and Sustrans to develop an approach to re-designating the road space.
Other roads will be closed this week with other changes expected over the coming weeks.
Council Leader Adam McVey said “The way we move around the city has changed significantly over recent weeks and it’s clear that we need to respond to this.
“We’ve been working closely with the Scottish Government to develop measures to help pedestrians and cyclists travel safely while remaining socially distant, so we’re delighted that Transport Scotland has confirmed funding to support local authorities to meet this challenge.
“Our commitment to encouraging and facilitating safer, more convenient walking and cycling in Edinburgh remains as strong as ever.
“We want to ensure that our city can support essential journeys and let local people access their local open spaces by creating safe, accessible routes to do so.”
This location has been identified in close dialogue with relevant Council services and Police Scotland who have expressed concerns in each area.
Further emergency measures are being investigated for implementation in the weeks beginning 4 May and 11 May and these will be communicated as soon as possible.